The threat of high-speed and strong maneuvering targets is increasing day by day. In order to effectively deal with the air-to-space attack of high-speed and strong maneuvering targets， this paper focuses on the technology of multi-missile cooperative detection and interception coverage. The cooperative coverage method of multi-interceptor missiles in mid-terminal guidance shift and terminal guidance phase is systematically analyzed from the aspects of coverage mechanism， coverage model， cooperative algorithm and so on. This paper studies six key issues： “field of view occlusion”， “anti-collision”， “game strategy”， “spatial configuration”， “multi-objective optimization” and “swarm intelligence algorithm”， and expands the research idea of multi-missile cooperative interception. it provides a reference for high-speed and strong maneuvering target interception technology.