Equipment support affects the completion quality of combat missions and even directly affects the success or failure of missions. Optimized scheduling of equipment support is the key to improve the efficiency of equipment support system. Aiming at the characteristics of two-layer decision making and combinatorial optimization of equipment support system， an optimized pre-scheduling model for equipment support based on two-layer programming is proposed. The operation process and modeling framework of the equipment support system are analyzed. Combining with the combinatorial optimization problem， a two-layer programming model is established. The upper layer is a coarse-grained layer， using the MTSP method and the lower layer is a fine-grained layer， using the JSP method. An example analysis shows that the proposed method has open structure and adaptive parameters in large-scale system scheduling optimization.