In recent years， the “Loyal Wingman”， which operates manned and unmanned aerial vehicles in collaboration， has attracted much attention due to its potential to subvert traditional air combat modes. This paper studies the progress of the “Loyal Wingman” project in the United States， Russia， Australia and some other countries， and predicts its future development trends. Based on this， and combined with penetrating counter air combat scenarios such as situational awareness， electronic countermeasures， distributed killing， soft penetration and hard penetration， we thoroughly analyzed the operational requirements， operational processes， and operational application modes of the “Loyal Wingman” in system of systems confrontation. which can provide reference for the research of offensive and defensive system of systems confrontation.