Based on the public intelligence information and performance parameters of US ground-based midcourse defense system, a method of threat control zone of ballistic missile defense is proposed. An analysis model of threat control zone of US ground-based midcourse defense is constructed. The threat control zone of US ground-based midcourse defense in the two cases of GBI in flight keeping line-of-sight communication with base and supported by multiple IFICS data terminals (IDT) is simulated, which will contribute to understand the capabilities of US ground-based midcourse defense more thoroughly and accurately.