Aiming at the uncertainty problem of hypersonic vehicles， a tracking strategy combining active disturbance rejection control and integral sliding mode control is proposed. The hypersonic vehicle model is transformed into a velocity subsystem and an altitude subsystem， where the velocity subsystem is a first-order system， and the altitude subsystem consists of the altitude loop， track angle loop， and pitch angle loop. Tracking differentiator is used to arrange the transition process of the system， and extended state observer is used to estimate the total disturbance. The integral sliding mode control law is designed to replace the nonlinear state error feedback control law. The results show that the designed tracking control strategy has strong robustness to hypersonic vehicle uncertainty. Compared with the traditional sliding mode active disturbance rejection control， it has more advantages in adjustment time， tracking accuracy and control signal smoothness.